TMM of FOP:一類藥物 | Celecoxib 塞來昔佈

VII. CLASSES OF MEDICATIONS (TABLE 1) | 藥物分類(表1)

CLASSI MEDICATIONS | 一類藥物 | Celecoxib 塞來昔佈


GENERIC | 通稱:Celecoxib 塞來昔佈

TRADE | 品名:Celebrex 西樂葆

CLASS | 分類:

Cyclooxygenase-2 inhibitor 環氧化酶-2抑制劑

PROPOSED MECHANISM OF ACTION AS ITRELATES TO FOP | 與FOP相關的作用機制:

Anti-inflammatory and potent antiangiogenic; symptomatic relief during a flare-up; Potential use in prevention by inhibiting production of inflammatory prostaglandins

抗炎和抗血管生成; 緩解急性發作期間的癥狀;通過抑制炎癥前列腺素的生成,有潛在的預防作用。

MAJOR SIDE EFFECTS | 主要副作用:

~ gastrointestinal bleeding 消化道出血

~ impaired renal function 腎功能受損

~concern about cardiovascular and cerebrovascular risks 有心腦血管風險

~NOT TO BE TAKEN BY PATIENTS WITH KNOWN ALLERGIES TO SULFONAMIDES OR BY PATIENTS WITH ASPIRIN-SENSITIVE ASTHMA

對磺胺類藥物、阿司匹林過敏的患者或敏感性哮喘患者不能服用

DOSING | 劑量:

Peds and Adults: 100-200 mg po bid for maintenance, at discretion of M.D.

兒童和成人:100-200mg,隔日服用,具體用量遵醫囑。

-For acute & chronic flare-ups, not to exceed maximum anti-angiogenic dose of 250 mgs/M 2 PO bid or 6 mg/kg PO bid (whichever is lower; rounded-up or roundeddown to the closest multiple of 100 mg) and not to exceed a maximum total daily dose of 600 mgs. for more than 16 months. Medication should be taken with a fatty snack for maximum absorption. Although used compassionately in children, not yet approved for pediatric use.

對於急慢性發作,不超過250mgs/M2 或 6mg/kg ,隔日用藥(以較低用量為準;最接近100mg的倍數),用藥超過16個月,每日最大用藥劑量不能超過600mg。藥物與含有脂肪類的零食一起服用,可以幫助最大程度的吸收。兒童用藥酌情,尚未批準用於兒科。

-Patients should be monitored for adequate hepatic and renal function.

需要檢測患者的肝腎功能是否能夠承受。

-Use with caution in FOP patients with a history cardiovascular disease or in older FOP patients who are severely immobilized or completely nonambulatory.

有心血管病史的FOP患者或嚴重不能活動或不能走動的年長FOP患者應謹慎使用。

– MUST NOT BE TAKEN BY PATIENTS WHO ARE ALLERGIC TO SULFONAMIDES OR BY PATIENTS WITH ASPIRIN-SENSITIVE ASTHMA.

對磺胺類藥物、阿司匹林過敏的患者或敏感性哮喘患者不能服用。

GENERIC | 通稱:Indomethacin 吲哚美辛

TRADE | 品名:Indocin 消炎痛

CLASS | 分類:

Non-steroidal antiinflammatory medication (non-specific cox-1 and cox-2 inhibitor)

非類固醇類抗炎藥(非特異性Cox-1和Cox-2抑制劑)

PROPOSED MECHANISM OF ACTION AS ITRELATES TO FOP | 與FOP相關的作用機制:

Anti-inflammatory and antiangiogenic; symptomatic relief during a flare-up; Potential use in prevention by inhibiting production of inflammatory prostaglandins

抗炎和抗血管生成; 緩解急性發作期間的癥狀;通過抑制炎癥前列腺素的生成,有潛在的預防作用。

MAJOR SIDE EFFECTS | 主要副作用:

~ gastrointestinal bleeding 胃腸道出血

~ impaired renal function 腎功能受損

DOSING | 劑量:Peds: 2-4 mg/kg/day PO; or 150-200 mg/day (whichever is less); divided tid Adult: 50 mg PO tid or Indocin – SR (sustained release) at a dose of 75 mg. PO bid. (Medication must be taken with food).

兒童:每天口服,2-4mg/kg:或每天口服,150-200mg/kg(以較少者為準):

成人:每日三次,口服50mg。(必須用食物服用藥物)。

本文譯自:

THE MEDICAL MANAGEMENT OF FIBRODYSPLASIA OSSIFICANS PROGRESSIVA: CURRENT TREATMENT CONSIDERATIONS

進行性骨化性纖維發育不良(FOP)的醫療管理:當前治療的註意事項

VII. CLASSES OF MEDICATIONS (TABLE 1) |藥物分類(表1)

CLASS II MEDICATIONS | 一類藥物

From The International Clinical Council on FOP (ICC) & Consultants:

來自國際臨床理事會的FOP(ICC)專傢和顧問:

發表於:2021.05


老F譯. 微信: Aspirinic

B站欄目:魚缸裡的老F

FOP微信群主:

明明:微信號: gogoniluyo

方方:微信號: lengmou1314520

微信公眾號搜索:天使的珊瑚FOP關愛之傢

赞(0)