VII. CLASSES OF MEDICATIONS (TABLE 1) | 藥物分類（表1）
CLASSI MEDICATIONS | 一類藥物 | Celecoxib 塞來昔佈
GENERIC | 通稱：Celecoxib 塞來昔佈
TRADE | 品名：Celebrex 西樂葆
CLASS | 分類：
Cyclooxygenase-2 inhibitor 環氧化酶-2抑制劑
PROPOSED MECHANISM OF ACTION AS ITRELATES TO FOP | 與FOP相關的作用機制：
Anti-inflammatory and potent antiangiogenic; symptomatic relief during a flare-up; Potential use in prevention by inhibiting production of inflammatory prostaglandins
抗炎和抗血管生成; 緩解急性發作期間的癥狀;通過抑制炎癥前列腺素的生成，有潛在的預防作用。
MAJOR SIDE EFFECTS | 主要副作用：
~ gastrointestinal bleeding 消化道出血
~ impaired renal function 腎功能受損
~concern about cardiovascular and cerebrovascular risks 有心腦血管風險
~NOT TO BE TAKEN BY PATIENTS WITH KNOWN ALLERGIES TO SULFONAMIDES OR BY PATIENTS WITH ASPIRIN-SENSITIVE ASTHMA
對磺胺類藥物、阿司匹林過敏的患者或敏感性哮喘患者不能服用
DOSING | 劑量：
Peds and Adults: 100-200 mg po bid for maintenance, at discretion of M.D.
兒童和成人：100-200mg，隔日服用，具體用量遵醫囑。
-For acute & chronic flare-ups, not to exceed maximum anti-angiogenic dose of 250 mgs/M 2 PO bid or 6 mg/kg PO bid (whichever is lower; rounded-up or roundeddown to the closest multiple of 100 mg) and not to exceed a maximum total daily dose of 600 mgs. for more than 16 months. Medication should be taken with a fatty snack for maximum absorption. Although used compassionately in children, not yet approved for pediatric use.
對於急慢性發作，不超過250mgs/M2 或 6mg/kg ，隔日用藥（以較低用量為準；最接近100mg的倍數），用藥超過16個月，每日最大用藥劑量不能超過600mg。藥物與含有脂肪類的零食一起服用，可以幫助最大程度的吸收。兒童用藥酌情，尚未批準用於兒科。
-Patients should be monitored for adequate hepatic and renal function.
需要檢測患者的肝腎功能是否能夠承受。
-Use with caution in FOP patients with a history cardiovascular disease or in older FOP patients who are severely immobilized or completely nonambulatory.
有心血管病史的FOP患者或嚴重不能活動或不能走動的年長FOP患者應謹慎使用。
– MUST NOT BE TAKEN BY PATIENTS WHO ARE ALLERGIC TO SULFONAMIDES OR BY PATIENTS WITH ASPIRIN-SENSITIVE ASTHMA.
對磺胺類藥物、阿司匹林過敏的患者或敏感性哮喘患者不能服用。
GENERIC | 通稱：Indomethacin 吲哚美辛
TRADE | 品名：Indocin 消炎痛
CLASS | 分類：
Non-steroidal antiinflammatory medication (non-specific cox-1 and cox-2 inhibitor)
非類固醇類抗炎藥（非特異性Cox-1和Cox-2抑制劑）
PROPOSED MECHANISM OF ACTION AS ITRELATES TO FOP | 與FOP相關的作用機制：
Anti-inflammatory and antiangiogenic; symptomatic relief during a flare-up; Potential use in prevention by inhibiting production of inflammatory prostaglandins
抗炎和抗血管生成; 緩解急性發作期間的癥狀;通過抑制炎癥前列腺素的生成，有潛在的預防作用。
MAJOR SIDE EFFECTS | 主要副作用：
~ gastrointestinal bleeding 胃腸道出血
~ impaired renal function 腎功能受損
DOSING | 劑量：Peds: 2-4 mg/kg/day PO; or 150-200 mg/day (whichever is less); divided tid Adult: 50 mg PO tid or Indocin – SR (sustained release) at a dose of 75 mg. PO bid. (Medication must be taken with food).
兒童：每天口服，2-4mg/kg：或每天口服，150-200mg/kg（以較少者為準）：
成人：每日三次，口服50mg。（必須用食物服用藥物）。
本文譯自：
THE MEDICAL MANAGEMENT OF FIBRODYSPLASIA OSSIFICANS PROGRESSIVA: CURRENT TREATMENT CONSIDERATIONS
進行性骨化性纖維發育不良（FOP）的醫療管理：當前治療的註意事項
VII. CLASSES OF MEDICATIONS (TABLE 1) |藥物分類（表1）
CLASS II MEDICATIONS | 一類藥物
From The International Clinical Council on FOP (ICC) & Consultants:
來自國際臨床理事會的FOP（ICC）專傢和顧問：
發表於：2021.05
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